 The
mission of the CIA-MR is to
apply magnetic resonance technology to fundamental problems in
engineering and the physical sciences.
CIAMR HomeCIAMR PersonnelCIAMR FacilitiesMR-PET Scanner DevelopmentMagnetic LevitationMR Compatibility of Medical DevicesMR Analysis of Bioreactor Structure and FunctionIndustrial NMR ApplicationsMRI of Wood3D MRI of FoamTissue EngineeringMRI of KneesMicro NMR CoilsDepartment of RadiologyUniversity of Minnesota |
MR Analysis of Bioreactor
Structure and Function NMR Investigations of Hollow Fiber Bioreactors at the CIA-MR Mammalian cell culture is of fundamental importance in biotechnology and is the focus of significant research efforts at the level of the basic sciences and engineering. Hollow fiber based cell culture systems are a principle technology used in the production of important mammalian cell products such as monoclonal antibodies, ex vivo manipulation and expansion of hematopoietic stem cells for gene and cancer therapies, and in bioartificial organ development. On going research at the CIA-MR focuses on using magnetic resonance imaging and spectroscopy to understand the relationship between the physical conditions existing within a bioreactor (fluid flow, pH, oxygen and nutrient concentrations) and the cell growth distribution and metabolic state of the cells. An understanding of these complex relationships will facilitate the optimization of these devices. Below is a brief sampling of some of our recent work conducted in collaboration with Cellex Biosciences. Please direct any questions or comments to the Webmaster (director@ciamr.drad.umn.edu) 1. NMR Imaging of Fluid Velocity Profiles in a Hollow Fiber Bioreactor 2. Visualization of Advancing Cell Growth Within a HFBR using Diffusion weighed MRI 3. Cell Growth Patterns Within a HFBR incorporating enhanced transmembrane flow
4. NMR Microscopy of a Model Micro-Bioreactor 5. Specialized NMR hardware Developed at the CIA-MR |
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